My name is Eric – I‘m 46 and saw a doctor for fatigue at 17. I lived fairly normally if a little subdued by lack of endurance at times. But then, 12 years ago I fell into a nosedive after moving to South Florida.

My name is Eric – I‘m 46 and saw a doctor for fatigue at 17. I lived fairly normally if a little subdued by lack of endurance at times. But then, 12 years ago I fell into a nosedive after moving to South Florida.

Our Tissue Bank, set up in 2010, serves as a procurement and distribution centre of human allograft tissues. These are provided as non-viable allografts, preserved by freezing or freeze drying and sterilized by gamma irradiation.
Tata Memorial Hospital, Mumbai has provided training to our staff & Dr. Ankit Mathur, Consultant – Transfusion Medicine & Transplant Immunology in BMST has a diploma in Tissue Banking from the University of Singapore.

Presently we have restricted our services to providing bone allografts. Bone pieces which are discarded after knee & hip replacement surgeries are collected after informed consent from patients at different hospitals. These bones are cleaned, sterilized, freeze dried and gamma irradiated before issuing to hospitals as surgical implants

Bone procurement:

1. The bone tissues that are discarded as biological waste, after the total knee replacements, hip joint replacements, hemiarthroplasty, and amputations and so on are instead donated by the patients undergoing these procedures along with their written consent. The patient (donor) details are kept confidential
2. They are procured under sterile conditions in the operation theatres at the hospital.
3. Tissue and blood samples from each donor are given a barcode for identification, track-ability & trace-ability.
4. Potential donors are evaluated and strict donor selection criteria are followed. All donor blood samples are screened for
a. Anti HIV 1 & 2 Antibody
b. Anti HBS Antigen
c. Anti HCV Antibody
d. Syphilis
e. Malaria

Processing & preservation:

1. The tissues are processed by washing, pasteurization and alcohol therapy to destroy microorganisms
2. The bones are cut into smaller bits or powdered.
3. They are freeze dried to remove 95% of moisture and packaged under sterile conditions.
4. The products are irradiated by Gamma ray at a dose of 25 Kilo Gray units from Cobalt 60 source at Microtrol Sterilization Centre Pvt limited, Bangalore.
5. After this processing the tissues are ready for use as allografts.
6. They can be stored at room temperature for 3 years.
7. The products are labelled appropriately along with the original donor barcode ID.

Measures to minimize post-allograft-transplant reactions:

1. The steps in the processing including freezing & freeze-drying destroy the tissue antigens. Therefore there is very little risk of HLA mediated immunological reactions.
2. The measures such as donor screening, screening for transmissible infections, sterilization and gamma irradiation ensure the risk of transmission of infections is extremely small.

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Issue of allografts:

The allografts are issued to hospitals / surgeons / dental surgeons on written, signed, requests. The hospital / clinician may store them at room temperature for up to 3 years. To ensure sterility, the packaging has to be removed just prior to use of the tissues.

Recovery of processing costs:

No payment is made to the donor or hospital for the tissues as these are donated after informed consent, voluntarily. The minimum testing, processing and other costs are recovered from patients / hospitals.

 

Experience:

Since inception, we have been able to collect and distribute close to 3000 bone allografts. We have so far supplied bone allograft to hospitals in:-
Bangalore | Chennai | Coimbatore | Chittur | Jhansi | Kanyakumari | Mangalore | Mysore | Trivandrum

Hospitals using our Tissue Bank in Bangalore: